highly significantP ≤0.05
P -values ≤0.05 were considered as significant or highly significant when ≤0.01 (given as * P ≤0.05; ** P ≤0.01; *** P ≤0.001; **** P ≤0.0001.
P -values ≤0.05 were considered as significant or highly significant when ≤0.01 (given as * P ≤0.05; ** P ≤0.01; *** P ≤0.001; **** P ≤0.0001.