at the limit of significancep <0.001
The mean PI values were statistically significantly superior or at the limit of significance in epithelioid and osteoblastic osteosarcomas, compared with fibroblastic and central low-grade ones, both for Ki67 ( p <0.001, ANOVA test), cyclin D1 ( p =0.070, ANOVA test) and p53 ( p =0.010, ANOVA test) (Table 2 ).