Pathway analysis demonstrated that the differentially expressed transcripts comprised key pathways important for MEC secretory differentiation, including PI3K/Akt signaling, fatty acid biosynthesis, triglyceride biosynthesis and the mammary gland transition from pregnancy to lactation (although this did not quite reach statistical significance, padj = 0.07), among others (Fig. 3 B).
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PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development.
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