Virological and Immunological Outcomes of an Intensified Four-Drug versus a Standard Three-Drug Antiretroviral Regimen, Both Integrase Strand Transfer Inhibitor-Based, in Primary HIV Infection.

At multivariable analysis, although none of the analyzed factors were significantly associated with low-level HIV-DNA achievement, both a higher level of HIV-1 DNA at baseline and a later start of the therapy after HIV diagnosis showed a borderline significance in the association, with a decreased chance of low viral reservoir achievement (aHR= 0.30 per each HIV-1 DNA log higher, p = 0.052; aHR = 0.09 for patients starting ART at Fiebig stage IV versus stages I/II, p = 0.058) ( Table 3 ). 2.3.

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