Pharmacodynamic evaluation of the XOR inhibitor WN1703 in a model of chronic hyperuricemia in rats induced by yeast extract combined with potassium oxonate.

Curr Res Pharmacol Drug Discov · 2022 · PMC9026663 · PMID 35465446

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a decreasing trendno p-value reported

Compared with the MG group, the creatinine levels in the drug-administration groups showed a decreasing trend, but not significantly ( P > 0.05).

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an increasing trendno p-value reported

With the remarkable improvement in living standards in some parts of the world, intake of sugar, fat, and protein has increased significantly, and the global prevalence of hyperuricemia has shown an increasing trend ( Dehlin et al., 2020 ).

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