Association of Elevated Expression Levels of <i>COL4A1</i> in Stromal Cells with an Immunosuppressive Tumor Microenvironment in Low-Grade Glioma, Pancreatic Adenocarcinoma, Skin Cutaneous Melanoma, and Stomach Adenocarcinoma.

J Pers Med · 2022 · PMC9029283 · PMID 35455650

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highly significantno p-value reported

In SKCM and STAD, macrophage signatures showed a highly significant correlation with COL4A1 expression levels, unlike those of CD8 + T cells, indicating the potential effect of high COL4A1 expression on the infiltration of macrophages but not on CD8 + T cells as an immune modulator for tumor progression in the TME.

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