IQF characterization of a cathepsin B-responsive nanoprobe for report of differentiation of HL60 cells into macrophages.

This cell differentiation system is selected because (1) it exhibits a fairly fast differentiation rate: 80% into macrophages or granulocytes within 3 days; 22 (2) a fairly significant difference in the expression level of lysosomal cathepsin B (Cat B) between the parent and daughter cells is associated with the cell differentiation process: 5–10 times in macrophages and 1.5–2 times in granulocytes relative to HL60 cells; 22 (3) peptide substrates of Cat B have been well document

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