Pain Relief after Stereotactic Radiotherapy of Pancreatic Adenocarcinoma: An Updated Systematic Review.

Impact of Radiotherapy Dose on Pain Relief The linear regression of overall response rate of pain after SBRT, based on the equivalent dose in 2 Gy per fraction (EQD2, α/β ratio = 10), showed a positive trend with increased doses, but only when the analysis was performed without weighting the results based on the number of patients in the individual case series ( Figure 5 ).

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Therefore, the analysis was repeated, after removing this result, and showed a highly significant positive effect of higher EQD2 on pain relief ( p : 0.004 and p : 0.005 for unweighted and weighted analysis, respectively) ( Figure S1 ). 2.4.

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