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Direct Detection of Antibiotic Resistance in Chinese <i>Helicobacter pylori</i> Clinical Isolates by Sequencing-Based Approach.

J Healthc Eng · 2022 · PMC9033385 · PMID 35463681

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an increasing trendno p-value reported
The widespread use of eradication therapeutic regimens, consisting of at least two antimicrobial agents, has recently shown that the resistance of Helicobacter pylori to antimicrobial agents such as clarithromycin, fluoroquinolones like levofloxacin, and metronidazole shows an increasing trend year by year.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.