Aberrant overexpression of HOTAIR inhibits abdominal adipogenesis through remodelling of genome-wide DNA methylation and transcription.

Mol Metab · 2022 · PMC9034304 · PMID 35292404

Europe PMC DOI

hedged sentence

0.0610

closest p · 1.2× alpha

0.0610

boldest claim

The sentences

marginally significantp = 0.061so close (0.05 < p ≤ 0.1)

In Abd HOTAIR-OE cells, the occupancy of H3K27me3 was significantly enriched in the promoter region of SLITRK4 , and there was a marginally significant increase ( p = 0.061) in the promoter region of PITPNC1 ( Figure 5 C), suggesting that HOTAIR -associated histone modifications work together with DNA hypermethylation to constantly suppress the transcription of SLITRK4 and PITPNC1 .

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