Topical Chlorhexidine 0.2% versus Topical Natamycin 5% for the Treatment of Fungal Keratitis in Nepal: A Randomized Controlled Noninferiority Trial.

Ophthalmology · 2022 · PMC9037000 · PMID 34896126

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a nonsignificant trendno p-value reported

17 A systematic review of 2 subsequent small, underpowered randomized controlled trials found a nonsignificant trend favoring chlorhexidine over natamycin in “curing” by 21 days (relative risk, 0.70; 95% confidence interval [CI], 0.45–1.09). 11 , 18 , 19 Chlorhexidine has the additional advantages of being inexpensive, easy to formulate, and generally well tolerated.

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