Unraveling the Genetic Architecture of Hepatoblastoma Risk: Birth Defects and Increased Burden of Germline Damaging Variants in Gastrointestinal/Renal Cancer Predisposition and DNA Repair Genes.

Although no significant results were found, mainly due to the small size of the sample, when we compared the distribution of individuals with craniofacial or kidney defects according to risk stratification, a marginally significant result was obtained ( p -value = 0.10), which can indicate a tendency of individuals with high-risk status to be more likely to present craniofacial defects, while individuals with less severe status are more prone to have kidney defects ( Supplementary Figure S1 ).

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