NOGEA: A Network-oriented Gene Entropy Approach for Dissecting Disease Comorbidity and Drug Repositioning.

Consistent with previous research [4] , a highly significant correlation occurred between the average DDE score of each bin and the enrichment fold of hits for known DDIs ( R 2 = 0.75, P = 2.2E − 16; Fig. 3 B), indicating a high likelihood that a drug will successfully treat a disease if the drug is capable of strongly perturbing the local module of master genes in the interactome.

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