Shared inflammatory and skin-specific gene signatures reveal common drivers of discoid lupus erythematosus in canines, humans and mice.

P values ​< ​0.05 were considered significant, with P ​< ​0.01 as highly significant. 3 Results 3.1 Canine gene expression analysis reveals key immune and skin genes upregulated in DLE versus healthy controls We isolated RNA from FFPE skin curls from six canine DLE and five healthy canine patients (clinical characteristics in Table 1 ).

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