Remarkably, this is already evident for COVID-19: highly significant sub-group effects have been seen in trials demonstrating the efficacy of dexamethasone 4 , 5 and tocilizumab 6 , and progress has been made to uncover their underlying biology 7 .
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Distinct clinical symptom patterns in patients hospitalised with COVID-19 in an analysis of 59,011 patients in the ISARIC-4C study.
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