It is reported that there was a highly significant increase of interleukin 6 (IL-6) at day 1 after both the 1st (∼1.5×) and the 2nd dose (∼2×) of BNT162b2 mRNA vaccine in naive vaccinees ( 21 ), while tumor necrosis factor alpha (TNF-α) also showed a significant increase after the 2nd vaccination ( 21 ).
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Correlation of Immunogenicity and Reactogenicity of BNT162b2 and CoronaVac SARS-CoV-2 Vaccines.
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