Reappraising the Value of HIV-1 Vaccine Correlates of Protection Analyses.

The infection rate in the RV144-like, bivalent gp120 group was somewhat higher than that in control animals (i.e., slightly worse than no protection), whereas there was a nonsignificant trend toward protection in the pentavalent gp120 group.

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Whatever the influence of the observed differences in Fc glycosylation between the two adjuvant groups, antibodies capable of mediating ADCC, ADCP, and ADCD (antibody-dependent complement deposition) responses were consistently better induced with MF59 than with alum; the differences between the adjuvant groups were highly significant ( 15 ).

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