Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis.

Sci Adv · 2022 · PMC9045615 · PMID 35476434

Europe PMC DOI

hedged sentences

0.0790

closest p · 1.6× alpha

0.0790

boldest claim

The sentences

a favorable trendP = 0.079so close (0.05 < p ≤ 0.1)

There were also increased responses toward FABP7 and SNAP91, but only significant compared to one of the control cohorts (FABP7 MS versus HC and SNAP91 MS versus OND), while the respective remaining groups showed a favorable trend: FABP7 MS versus OND ( P = 0.079) and SNAP91 MS versus HCs ( P = 0.112).

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did not achieve significanceno p-value reported

Comparison of FABP7 and SNAP91 reactivity in the untreated cohort did not achieve significance in one of the two comparisons, because of insufficient cohort size ( Fig. 3A ); however, clear trends were observed for increased reactivity to autoantigens in the patient group.

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