Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling.

In the absence of Cbf5 and Nop58, we observe that the correlated loss of pseudouridine (p-value = 5.5e-05, Brown’s method) and 2 ́O-methyl (p-value = 1.5e-16, Brown’s method) modifications is highly significant, respectively ( Figure 1D and E and Figure 1—figure supplement 3E,F ).

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