The application of quality by design in the development of the liquid chromatography method to determine empagliflozin in the presence of its organic impurities.

RSC Adv · 2020 · PMC9049826 · PMID 35493885

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may be significantno p-value reported

There may be significant implications for health when these unwanted structures are consumed, because of the teratogenic, mutagenic or carcinogenic potential of some compounds, especially in continuous use drugs.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.