Estrogen, the Peripheral Immune System and Major Depression - A Reproductive Lifespan Perspective.

The consequences of these variations may be significant when attempting to address consequences of immunogens that exhibit host-specific patterns of infection, such as cytomegalovirus ( Mestas and Hughes, 2004 ; Masopust et al., 2017 ), leading some researchers to suggest that rodents poorly recapitulate human injury or disease-associated inflammatory cascades and to advocate caution in the utilization of rodent models for immune-focused research questions ( Seok et al., 2013 ).

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