11,19 These studies indicate that there may be significant differences in the metabolic phenotypes of naturally occurring Tregs in vivo and in vitro , which are related to the environment, physiological/pathological state of Treg cells, different species, and different anatomical locations. 3.6 Inhibition of glycolysis and fatty acid oxidation alters the number and function of mice Treg cells To determine the effect of metabolic disorders on mouse spleen Treg cells, we treated sepsis mice with either 2-DG or etomoxir and observed changes in the number and function of freshly isolated splenic Treg cells.
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Glycolytic and lipid oxidative metabolic programs are essential for freshly-isolated regulatory T cells in mice with sepsis.
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