Prostate-Centric Versus Bony-Centric Registration in the Definitive Treatment of Node-Positive Prostate Cancer with Simultaneous Integrated Boost: A Dosimetric Comparison.

It is conceivable that the dosimetric effect for conventionally fractionated patients is less because any misalignments are spread out over more fractions 3 , 4 ; however, our analysis showed that undercoverage was highly significant even on a per-patient basis, suggesting that treatment over a larger number of fractions (or examining more CBCTs) would not change our findings.

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