Given the crucial role of HMGA1 in conferring TNBC aggressiveness through the modulation of specific gene networks and pathways, we dissected other HMGA1-mediators of cancer cell motility and found a highly significant association with the expression of stathmin protein in BC patients, which was further supported by a clinical correlation of the expression of both genes.
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HMGA1 positively regulates the microtubule-destabilizing protein stathmin promoting motility in TNBC cells and decreasing tumour sensitivity to paclitaxel.
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