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Interleukin-6 mediated inflammasome activation promotes oral squamous cell carcinoma progression via JAK2/STAT3/Sox4/NLRP3 signaling pathway.

J Exp Clin Cancer Res · 2022 · PMC9069786 · PMID 35513871

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a decreasing trendno p-value reported
There are more than 300,000 new cases of OSCC yearly, and the age of onset displays a decreasing trend year by year [ 2 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.