highly significantP < 0.0001
This total of 74.5% (175 of 235) represents a highly significant enrichment relative to the 33.3% of all cytosines in the mitogenome that are found in a CpG or CHG context (χ 2 = 178.9; P < 0.0001), supporting the expected role of 5mC modifications in numt sequence divergence.