Twelve Variants Polygenic Score for Low-Density Lipoprotein Cholesterol Distribution in a Large Cohort of Patients With Clinically Diagnosed Familial Hypercholesterolemia With or Without Causative Mutations.

When we explored the correlation between LDLc‐score and LDL‐C levels in subjects who were FH/M+ or FH/M−, a positive trend was observed among subjects who were FH/M− ( R , 0.13; P =0.0006) that was even more marked among subjects who were FH/M+ ( R , 0.15; P <0.0001) (Figure 3 ).

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