Perceived social isolation is correlated with brain structure and cognitive trajectory in Alzheimer's disease.

In the SCD-MCI group, the lonely patients were older, had fewer years of education, had lower ADAS-Jcog baseline scores, and had a greater annual degree of change in ADAS-Jcog score, although this was marginally significant ( P = 0.08, Cohen’s d = − 0.801).

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