PARP1-PKM2 Axis Mediates Right Ventricular Failure Associated With Pulmonary Arterial Hypertension.

Consistent with our in vitro and in vivo observations, the expression levels of PARP1, phosphorylated PKM2, total PKM2, pSTAT3, cMYC, hexokinase 2, lactate dehydrogenase, and Nudix hydrolase 1 were markedly increased in WT animals subjected to PAB, whereas these effects were significantly blunted in mutant PAB mice, except for Nudix hydrolase 1, which exhibited a decreasing trend ( Figure 7H ).

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