Longitudinal analyses reveal distinct immune response landscapes in lung and intestinal tissues from SARS-CoV-2-infected rhesus macaques.

At different time points after infection (3–10 dpi), we found that ACE2 and TMPRSS2 were mainly expressed in enterocytes ( Figure 6 G), and ACE2 expression exhibited an increasing trend from 3 to 7 dpi, whereas TMPRSS2 levels decreased during the infection period ( Figure 6 H).

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In lung tissues, cluster 4 (227 genes) including “regulatory T cell differentiation” genes showed a decreasing trend at 7–10 dpi ( Figures 3 H and S2 D).

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