Furthermore, in uEVs and cEVs, we also found previously characterized “highly stable” circ‐ARID1A, circ‐FAM13B, circ‐MAN1A2 and circ‐RHOBTB3, detected by rtqPCR independently in nonvesicular urinary samples of PCa patients (Vo et al., 2019 ) reinforcing the robustness of our approach and the highly significant enrichment of those circRNAs.
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Urinary extracellular vesicles contain mature transcriptome enriched in circular and long noncoding RNAs with functional significance in prostate cancer.
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