Deciphering the Underlying Mechanisms of Formula Le-Cao-Shi Against Liver Injuries by Integrating Network Pharmacology, Metabonomics, and Experimental Validation.

One-way analysis of variance and Student’s t -test were used to analyze the differences between groups, and p < 0.05 was considered statistically significant, while p < 0.01 was considered highly significant. 3 Results and Discussion 3.1 Network Pharmacology Analysis 3.1.1 Construction of Chemical Ingredient Database Ingredients in the three single herbs of LCS were manually collected, including 126 ingredients in A. ilicifolius (see Supplementary Figure S2 ), 50 in P. pulchellum (see Supplementary Figure S3 ), and 43 in C. cochinchinensis (see Supplementary Figure S4 ).

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