What Is the Minimum Clinically Important Change in Negative Symptoms of Schizophrenia? PANSS Based <i>Post-hoc</i> Analyses of a Phase III Clinical Trial.

However, it is important to bear in mind that the distribution-based statistical approaches showed a marked separation (MCID 3 , i.e., statistical effect size in terms of standardized mean difference = 0.6); and highly significant predictive power for the PANSS-FSNS scale for differentiating Minimally Improved from Clinically Unchanged status in terms of ROC measures (MCID 4 ; e.g., AUC = 0.7232) and the odds ratio (MCID 5 ; OR = 2.07).

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