Additive Effect of Parathyroid Hormone and Zoledronate Acid on Prevention Particle Wears-Induced Implant Loosening by Promoting Periprosthetic Bone Architecture and Strength in an Ovariectomized Rat Model.

Front Endocrinol (Lausanne) · 2022 · PMC9084285 · PMID 35546997

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an increasing trendno p-value reported

After the treatment of PTH alone, or ZOL alone, or combination therapy, significantly improved implant fixation was manifested with increased maximal pull-out force (F=23.4, df 5 and 24, p<0.01) and stiffness (F=4.696, df 5 and 24, p<0.01) in the PTH group and P+Z group, whereas no difference but an increasing trend was found under ZOL alone ( Figures 2C, D ).

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