From the 5th day to the 14th day after CCI, 10, 30 and 50 mg/kg Z-guggulsterone was injected intraperitoneally (CCI+Z-GS-L, CCI+Z-GS-M and CCI+Z-GS-H groups, respectively), and the PWMT and TWL showed an increasing trend, which was significantly different from that observed in the CCI+Veh group.
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Z-Guggulsterone Relieves Neuropathic Pain by Inhibiting the Expression of Astrocytes and Proinflammatory Cytokines in the Spinal Dorsal Horn.
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