Possible reasons are as follows: (1) Due to human subjects, it is difficult to obtain adipose tissue, resulting in a small sample size; (2) Obesity is a complex disease, and its occurrence is the result of the interaction of multiple genes [ 26 , 27 ], so methylation status of a single gene promoter sequence may not be significant.
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Association of CIDEB gene promoter methylation with overweight or obesity in adults.
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