Clinicogenomic Characteristics and Treatment of Young-Onset Colorectal Cancer Patients Treated With Palliative Therapy in Real-World Practice.

8 , 19 - 21 In the univariable Cox proportional hazards model with age treated as a continuous variable, patients of extreme ages showed tendencies toward increased hazard ratios for PFS1 and OS with marginal significance for nonlinear associations, consistent with a previous report. 13 Given that our dataset included only a limited number of patients diagnosed at < 30 years of age, further studies are required to confirm the poor prognoses of very YOCR patients and establish the adequate age cutoff for “young-onset” colorectal cancers.

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