Hem-1 regulates protective humoral immunity and limits autoantibody production in a B cell-specific manner.

Using ELISA assays on serum from Hem1 fl/fl Mb1Cre and WT mice, we found that Hem1 fl/fl Mb1Cre mice produced higher levels of anti-dsDNA relative to WT mice, and anti-smRNP autoantibodies appeared increased but did not quite reach statistical significance ( Figure 7D ).

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