Neoadjuvant chemoradiation alters the immune microenvironment in pancreatic ductal adenocarcinoma.

Our data show that a higher ratio of T regs to CD3 + T cells in the tumor compartment of CRT treated tumors correlate with poor prognosis. Density and spatial distribution of CD8 + T cells in CRT PDAC compared with treatment naive melanoma The increase in infiltration by CD8 + T cells induced by CRT was highly significant, and one key question is whether PDAC might hereby be converted into an immunotherapy-responsive “hot tumor.” 37 Melanoma is a classic example of a hot tumor, and therefore we sought to investigate how this level of infiltration into irradiated primary PDACs compare with treatment naive primary melanoma.

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