Plasma neurofilament light chain protein as a predictor of days in delirium and deep sedation, mortality and length of stay in critically ill patients.

In addition when patients who had one or no days in delirium or deep sedation (n=18) were compared with patients who had seven or more days in delirium or deep sedation (n=62) there was a highly significant difference at day three with mean plasma neurofilament light level of 37.8 pg/ml (SD 32.6) in patients with no or one day of delirium/deep sedation compared with 94.2 pg/ml (SD 74.3) in patients with seven or more days in delirium/deep sedation p<0.001.

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