Rap1a Activity Elevated the Impact of Endogenous AGEs in Diabetic Collagen to Stimulate Increased Myofibroblast Transition and Oxidative Stress.

Int J Mol Sci · 2022 · PMC9101126 · PMID 35562872

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a decreasing trendno p-value reported

Cardiac fibroblasts with RAGE showed a decreasing trend in SOD-1 expression when cultured on diabetic collagen but only diabetic cells were significant ( Supplementary Figure S4A–C ; one-way ANOVA non-diabetic p = 0.1823, diabetic p = 0.0172, and Rap1a KO p = 4298).

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