Induction of Brain Insulin Resistance and Alzheimer's Molecular Changes by Western Diet.

Immunohistochemical analysis using a 6E10 antibody directed against Aβ peptide ( Figure 7 ) revealed an increasing trend of Aβ deposits around cell nuclei from 4 to 12 months of age in Tg2576 mice maintained on the WD, when compared to control Tg2576 groups.

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In the hippocampus only in the 8M WD group, the levels of two assessed kinases, the active form of Akt and the inactive form of GSK-3β, showed a decreasing trend compared with age-matched controls.

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