IL-6 Responsiveness of CD4<sup>+</sup> and CD8<sup>+</sup> T Cells after Allogeneic Stem Cell Transplantation Differs between Patients and Is Associated with Previous Acute Graft versus Host Disease and Pretransplant Antithymocyte Globulin Therapy.

J Clin Med · 2022 · PMC9104003 · PMID 35566660

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borderline significanceno p-value reported

A significant increase in AKT (Thr308) phosphorylation was also observed for circulating CD3 + CD8 + T cells, whereas the mTOR (Ser2448) phosphoresponse reached only borderline significance for this cell subset.

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highly significantno p-value reported

of borderline significanceno p-value reported

PMA combined with TCR activation (anti-CD3 + anti-CD28) also caused a highly significant increase in the phosphorylation of AKT (Thr308), mTOR (Ser2448) and STAT3 (Ser727) for both T cell subsets, but an additional increase in STAT3 (Tyr705) phosphorylation of borderline significance was observed only for CD3 + CD8 + cells after combined PMA+TCR stimulation ( Table 2 ).

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