Space- and Time-Resolved Metabolomics of a High-Grade Serous Ovarian Cancer Mouse Model.

Bile acids ( Figure 2 k) showed an interesting increase at the TKO premalignant stages (20–36 %lifetime), a decreasing trend in the early disease stages (36–80 %lifetime), followed by an increase in the advanced stages. 3.3.

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SM showed an overall decrease in abundance in TKO mice, whereas Cer, the hydrolysis product of SM, showed an increasing trend ( Figure 1 a,b, Figures S5 and S6 ).

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