A general calculus of fitness landscapes finds genes under selection in cancers.

Likewise, the cohort integrals of representative oncogenes, such as PIK3CA , BRAF , KRAS , and NRAS , were all also highly significant ( P -value = 2.2 × 10 −57 , 9.4 × 10 −179 , 1.1 × 10 −63 , and 9.6 × 10 −45 , respectively) ( Fig. 2 D).

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