However, remarkably, the absence of HPSE-1 in both donor T cells and recipient mice resulted in a dramatic and highly significant increase in the frequency of diabetes-free mice from 0% in WT to ~60% in double KO mice ( Figure 2 B).
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Acute T-Cell-Driven Inflammation Requires the Endoglycosidase Heparanase-1 from Multiple Cell Types.
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