Cohesin-dependence of neuronal gene expression relates to chromatin loop length.

Elife · 2022 · PMC9106336 · PMID 35471149

Europe PMC DOI

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highly significantp<2.22e-16actually significant

RNA-seq showed highly significant overlap in gene expression between acute degradation of RAD21-TEV and genetic cohesin depletion in Rad21 lox/lox Nex Cre neurons (p<2.22e-16, odds ratio = 8.24 for all deregulated genes, odds ratio = 23.81 for downregulated genes; Figure 4a ).

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