A practical problem with Egger regression in Mendelian randomization.

PLoS Genet · 2022 · PMC9109933 · PMID 35507585

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closest p

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highly significantno p-value reported

We can see that with different coding schemes in Egger regression, not only the point estimates of the causal parameter varied (even from negative to positive), but also the p-values (from insignificant to highly significant), giving possibly opposite conclusions.

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