Burden of disease and associated complications of hepatitis a in children and adults in Mexico: A retrospective database study.

Although there is a substantial decrease in overall trends of HAV disease from years 2000 to 2019 (especially after year 2013), we can also observe a slightly increasing trend in hospitalizations and incidence from year 2017 until year 2019.

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However, since the year 2014 to 2019 there was an increasing trend in patients between 20–64 YoA that were hospitalized due to HAV + FHF or ALF infection ( Fig 4 ).

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Primary objectives Overall, there is evidence of a decreasing trend in HAV disease among children, however, there is an increasing trend in HAV disease and complications in older age groups, which is expected in countries with intermediate endemicity like Mexico.

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