Low expression of TMPRSS2-a SARS-CoV-2 internalization protease-associates with basal subtype of head and neck squamous cell carcinoma.

Although both of these comparisons showed a highly significant difference, the magnitude of the difference was much higher in the case of TMPRSS2 : in the TCGA dataset, the difference of medians between HPV-negative BA subtype patients vs all others was 3.59 and 0.3 for TMPRSS2 and FURIN , respectively.

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The comparison of CL vs BA and IMS vs BA groups showed significantly higher expression of FURIN in the BA subtype; however, the comparison of IMS vs CL did not show a significant difference in the TCGA dataset but a marginally significant difference in the UChicago dataset ( Table 2 , Fig 2 B).

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